Heparin Structure/Structural Analysis
- An heparin dodecasaccharide, containing two contiguous antithrombin binding sequences, have been described and characterized for the first time.
- HSQC correlation spectroscopy (HSQCcos) can extract chemically related signals from information-rich spectra obtained from complex mixtures such as heparin.
- Rapid pyrolysis is integrated with direct analysis in real time (DART) mass spectrometry to rapidly screen major glycosaminoglycans, including: heparin, chondroitin sulfate A, dermatan sulfate, and OSCS
Heparin and Cancer
- Heparin treatment attenuates tumor metastasis in mice by inhibiting P-selectin-mediated interactions of platelets with carcinoma cell-surface mucin ligands.